MK-677 Erectile Dysfunction – Does It Work?

Written by: Fab Fellas


MK-677 Erectile Dysfunction – Does It Work?

A lack of sexual desire or the ability to get hard can damage your self-confidence and your relationship. Yet a surprisingly high volume of men experience erectile dysfunction (ED) – and struggle to find an effective treatment.

It is estimated there are some 30 million men in the US that suffer from erectile dysfunction. The cause can be due to a number of issues – and recognizing the cause may influence your choice of ED treatment.

If you have been researching effective treatments for ED, you may have come across MK-677. This wonder drug has many purported benefits which include increasing bone density, improving sleep and even anti-aging.

MK-677 is also said to provide a solution that can help with erectile dysfunction. But this is where we get into controversial waters.

In this article, we’re going to take a deep dive to ask, what is MK-677, how it works, and determine whether it is an effective treatment for erectile dysfunction.

Three. Two. One.


Mk 677 and erectile dysfunction

MK-677 is an oral medication that also goes by the name Ibutamoren. The drug was originally marketed as an anabolic substance to increase body mass.

In other words, MK-677 stimulates hormone growth (GH). Hormone stimuli are important for increasing testosterone levels – and testosterone triggers your libido and puts you in the mood.

But the active ingredients in Ibutamoren also promote serum insulin growth factor 1 (IGF-1) which is needed to help with the production of nitric oxide – another naturally occurring chemical involved in making your penis erect.

Nitric oxide plays a central role in getting an erection by helping blood flow to the penis. A sufficient amount of blood is a requirement for maintaining a hard-on and achieving the desired level of sexual performance.

study published in Nature reveals a deficiency in GH and IGF-1 disturbs the male reproductive function, including a drop in sexual arousal and the ability to get an erection.


To understand how – and whether – MK-667 is an effective treatment for ED, we need to know the biological process that is involved in getting an erection.

When a man is sexually stimulated, the brain sends a neurotransmitter to the nerve cells in the penis. These neurotransmitters trigger the release of nitric oxide (NO) in the nerve and endothelial cells of the “corpora cavernosa” (shaft) of the penis.

NO activates soluble guanylyl cyclase, which increases cyclic guanosine monophosphate (cGMP) levels which regulates the activity of calcium channels and creates space for blood to flow into the penis. This is how an erection is formed.

But before the blood can flow, men have to have a sufficient amount of the sex hormone, testosterone. Low testosterone levels reduce blood flow.

It should be noted that low testosterone in erectile dysfunction is rare.

The manufacturers of MK-677 claim Ibutamoren can help with erectile dysfunction by targeting testosterone production and stimulating ghrelin receptors (GHSR) in the brain to help the secretion of NO into the penis.

In theory, MK-677 should wonder about the functioning of the male sex organ. But scientific studies don’t always translate into real-world solutions.

One study concluded that:

“While logic dictates that treating this underlying endocrinopathy [low testosterone] should reverse the ED, there is a lack of clinical evidence to support this expectation”. ~ Jacob Rajfer, MD, NCBI

There is no hard evidence to support the claim that MK-667 is an effective treatment for ED. Having said that, it could theoretically work – and empirical evidence (word-of-mouth) confirms that some men have successfully reignited their sex life using MK-677.

However, other users have reported a string of nasty side effects including ED getting worse whilst taking a course of MK-677.


Like most pharmaceutical drugs, MK-677 does have known side effects. Common complaints include an increase in appetite, anxiety, numbness, and muscle pain.

There are also reports that fly in the face of marketing claims that declare MK-677 improves muscle mass and increases sexual desire. Feedback surfacing within the SARMs (Selective androgen receptor modulators) community reports that MK-667 decreased libido whilst other users have reported a loss in bone mineral density and decreased insulin sensitivity.

Sports Integrity Australia (SIA) has also issued a warning that MK-677 is a banned substance and claims the product does not deliver on its claim to improve muscle mass. SIA even goes as far as declaring that Ibutamoren is a “poison”.

MK-677 is also shown to increase cortisol – the leading stress hormone that stimulates activity in the sympathetic nervous system. For men to get full erections, you need the opposite to happen – suppress cortisol and activate the parasympathetic nervous system.

Given such damning reports, we can only conclude that MK-677 does not achieve the results you may be led to believe in Ibutamoren marketing campaigns.


We believe there are alternative treatments that stimulate erectile function that is more effective and reliable than MK-677 – and other pharmaceutical drugs for that matter.

The most promising solution we’ve seen is NeoWave, an acoustic shock wave therapy (ASWT) that targets the formation of new blood cells and nerve endings. What’s more, it appears there are no nasty side effects.

ASWT involves massaging targeted areas on your penis with a small wand-like device that pulsates sound waves that stimulate the natural healing qualities of the body.

Sound waves have been shown to trigger neurogenesis – the process involved in the creation of new cells. By creating new cells, shock wave therapy stimulates the growth of penile tissue and provides space for blood flow to make the penis swell.


Whilst MK-677 and other over-the-counter oral medications make claims based on scientific studies that show erectile function relies on a train reaction of chemicals in the brain and corpora cavernosa, researchers have not found evidence that ED pills are effective.

In contrast, certified Urologists claim low-intensity shock wave therapy is effective in 75% of patients. This type of treatment is also proven to work, and is FDA-approved, for treating other conditions that target the restoration of new cells such as sports injuries and kidney stones. v